In this regard, increase the solubility of the antibiotic by adding sodium dezoksiholyata, thereby forming a mixture by dissolving giving a colloidal solution suitable for parenteral administration. At concentrations achievable in biological fluids, amphotericin B has more fungistatic rather than fungicidal action. Its possible mechanism of action is associated with the formation of compounds with sterol rings as part of the membrane of fungal cells. As a result, the membrane becomes permeable to intracellular clomiphene for men components. Mammalian cell membranes also contain sterols in their composition.In this connection, it was suggested that damage to human cells and fungal cells can develop through common mechanisms. In clinical practice, the formation of resistance to amphotericin from fungi of the genus Candida strains were found. Although when checking a small number of resistant isolates were obtained in vitro, but this occurred only after repeated subkulturirovanii.
Clinical Pharmacology When the scheme intravenous administration, when initially introduced 1-5 mg of amphotericin B per day, gradually increasing the dose to 0.65 mg per kilogram of body weight per day, the peak concentration of the drug in the plan amounted to approximately 2-4 mg / l. These peak concentrations were maintained in the interval between the injections of the drug, since the in plasma is about 24 hours. It is noticed that amphotericin B has high (more than 90%) to plasma proteins affinity and poorly dialyzed. Amphotericin slowly ekretiruetsya kidneys from 2% to 5% of the administered dose ekretiruetsya in biologically active form. After the cessation of treatment drug found in the urine for at least seven weeks. Kumupyativnoe urinary excretion of the drug over a seven day clomiphene for men observation period, approximately 40% of the administered drug. Details raspredepeniya clomiphene citrate dosage tissue metabolism and possible mechanisms of amphotericin B are unknown.
Indications for use:
Fungizone intravenous should be administered primarily to patients with progressive potentially fatal infections. The drug should not be used to treat common forms of fungal infections that manifest only positive results of skin tests or bacteriological tests. Fungizone Intravenous particularly suitable for the treatment of cryptococcosis (toruleza); North American blastomycosis; disseminated forms of candidiasis, coccidioidomycosis and histoplasmosis, mucormycosis (phycomycosis) caused by strains of the genus Mucor, Rhizopus, Absidia, Entomophthora, and Basidiobolus sporotrichosis (Sporotrichium schenckii), aspergillosis (Aspergillus fumigatus). Amphotericin B can help in the treatment of American mucocutaneous leyshmaniaza, however, is not the drug clomid for bodybuilding of choice for initial therapy.
Dosage and administration:
Adults and children: Fungizone should be administered by slow intravenous infusion over 6 hours. Initial daily dose should be 0.25 mg per kilogram of body weight dose clomiphene for men with a gradual increase to a level of 1.0 mg per kilogram of body weight, depending on the individual response and tolerability. In the range of 0.25-1.0 mg / kg daily dose should be maintained at the highest possible level, which is not accompanied by severe toxicities. In patients who are in critical condition, the daily dose can be effectively increased to a maximum reaching 1.5 mg / kg body weight. Since Fungizone slowly excreted, the drug can be administered at higher doses a day. Typically, a few months of treatment required. A shorter period of treatment can lead to an insufficient response or relapse. If the treatment is interrupted for more than 7 days, treatment should be resumed, starting with a low dose of 0.25 mg per kilogram of body weight, with a gradual increase in their.