Cases of overdose of fusidic acid is unknown.
Possible symptoms of an acute overdose: gastro-intestinal disorders, changes in the liver (changes in biochemical parameters, jaundice). Treatment : symptomatic and supportive therapy. Hemodialysis is not effective.
The interaction with other drugs
Pharmaceutically compatible with kanamycin, gentamicin, vancomycin, carbenicillin, with amino acid solutions with donor (whole) blood, infusion solutions containing lipids, to solutions for peritoneal dialysis with concentrated (> 20%) dextrose solution and . the calcium-containing drug
solution what is clomid compatible infusion solutions with the following:
– 0.9% sodium chloride intravenous infusion of sodium (1.2 mg / ml)
– 5% dextrose solution for intravenous infusion (2.1 mg / ml )
– lactate Ringer’s solution (1 mg / ml)
– sodium lactate solution for intravenous infusion (1 mg / ml)
– 0.18% chloride and sodium 4% dextrose solution for intravenous infusion (1 mg / ml);
-. 0.3% sodium chloride and 5% potassium dextrose intravenous infusion (1mg / ml)
In an appointment with drugs, the metabolism of which is associated with the system of cytochrome CYP ZA4 perhaps mutual inhibition of metabolism. When combined with inhibitors of 3-trihydroxy-3-methylglutaryl coenzyme A reductase inhibitors such as statins, increases the concentration of both drugs in blood plasma. In an application increased plasma concentrations of cyclosporine, anticoagulants, coumarin derivatives (need a dose adjustment when used , as well as its cancellation), protease inhibitors (ritonavir and saquinavir).Possible interaction with lincomycin and rifampicin, since they have the same path with fusidic acid excretion.
When combined with glycopeptides, fluoroquinolones what is clomid antagonism observed action.
With simultaneous use of fusidic acid with other antistaphylococcal antibiotics such penitsillazoustoychivymi penicillins, ampicillin, methicillin, cloxacillin. flucloxacillin, cephalosporins, erythromycin, rifampin, lincomycin, there is an additive or synergistic effects.
Should not be administered intramuscularly or subcutaneously.
When combined is assigned to another antibiotic for parenteral administration, the solutions are administered separately.
Do not appoint in patients receiving drugs that inhibit what is clomid.
During treatment should monitor liver function, especially patients concomitantly receiving hepatotoxic drugs, liver disease, biliary tract obstruction or in combination with drugs that have the same clearance with fusidic acid pathway, such as lincomycin and rifampicin. If during therapy Fuzidanatom developing hyperbilirubinemia with jaundice or without it, as well as increased activity of liver enzymes (transaminases, alkaline phosphatase) should stop the drug. The increased activity of “liver” enzymes and jaundice usually rapidly reversible upon discontinuation of the drug. Jaundice is more common in cases of rapid intravenous administration or excessive dosage.
Since competitively inhibits the binding of bilirubin to a protein, it should be used with caution in patients with impaired transport and metabolism of bilirubin. The cases of kernicterus in the newborn have not been observed, however, the drug should be used with caution in newborns with jaundice, acidosis, prematurity and infants with other serious diseases.
Adverse reactions from the side of hematopoiesis relate mainly white germ hematopoiesis and are observed with prolonged use the drug is usually more than 15 days, and its abolition regress.
The risk of developing acute renal failure usually have patients with jaundice patients in the presence of predisposing factors.
In rare cases, the concomitant use with inhibitors of 3-trihydroxy-3-methylglutaryl-coenzyme a reductase as a result of rhabdomyolysis in blood plasma increased levels of creatine, there are muscle weakness and myalgia, so these patients should be monitored carefully.
in severe infections requiring prolonged antibiotic therapy, can be administered in combination with other antistaphylococcal antibiotics, for example, penitsillazoustoychivymi penicillins, ampicillin, methicillin, cloxacillin. flucloxacillin, cephalosporins, erythromycin, rifampin, lincomycin, thereby achieving an additive or synergistic effect.
With rapid infusion, what is clomid causes spasm veins, thrombophlebitis and hemolysis of erythrocytes.
Thecontained 3.1 and 1.1 mmol of sodium mM phosphate.
Effects on ability to drive vehicles and the performance of potentially hazardous activities that require attention and speed of reaction
Affect the patient’s ability to drive vehicles and perform other potentially hazardous activities that require high concentration and speed of psychomotor reactions.
Powder for solution for infusion is 500 mg vial of clear glass with a rubber stopper and a metal cap with a plastic coating.
The sterile buffer solution 10 ml vial of 12 ml of clear glass with a rubber stopper and a metal cap with a plastic coating.
1 vial of powder what is clomidand 1 vial with a sterile buffer solution, along with instructions for use are placed in a pile of cardboard.